To investigate therapeutic effects of the method of Chinese and western medicine in the treatment of patients with vascular neurogenic headache and analysis of its pharmaceutical safety. Methods: A total of 156 cases of patients with vascular neurogenic headache were admitted and treated in the clinic of the Second Hospital of Beijing from June 2016 to January 2017. According to the random number table method, all the patients were divided into two groups: conventional western medicine group (conventional western medicine treatment, 78 cases) and combination of Chinese and western medicine group (western medicine combined with Chinese medicine treatment, 78 cases). The conventional western medicine treatment included: oral administration of Flunarizine Hydrochloride Capsules (5 mg/time, 1 time/day). Chinese medicine treatment included: oral adminiarestion of Qiangli Dingxuan Pills (1.4 g/time, 3 times/day). The improvements of headache, the clinical effect, the quality of life and the safety of medication were compared in the two groups after treatment. Results: The symptoms of headache and the quality of life in the two groups were all improved than that before treatment. After treatment, compared with conventional western medicine group, , headache was improved better (t=4.23, P<0.05) in the combination of Chinese and western medicine group, and with better clinical effects (Uc= 4.99, P<0.05). The quality of life including body physiological (PF) , psychological / emotional (RE), social function (SF) and general health (HT) were all improve compared with the conventional western medicine group (P<0.05), while the drug adverse reactions did not increase (P>0.05). Conclusion: The combination of conventional western medicine and traditional Chinese medicine is recommended for the treatment of vascular headache. It can improve headache symptoms and quality of life, and is safe in medication.