To observe the efficacy and safety of Xuesaitong soft capsule combined with phacoemulsification in treating non-proliferative diabetic retinopathy (NPDR) and cataract. Methods: A total of 108 cases of patients with NPDR combinded cataract (116 eyes) who were admitted in our hospital from January 2015 to June 2015 were randomly divided into control group with 54 cases (57 eyes with cataract) and observation group with 54 cases (59 eyes with cataract). All patients were treated with conventional hypoglycemic therapy and phacoemulsification. The patients in the observation group were received Xuesaitong soft capsule additionally from 2 weeks before the operation to 3 months after operation. The effect of NPDR, the sight and average visual defect, the corneal scattered photometric and the complications of phacoemulsification and the drug adverse reaction were observed. Results: The total effective rate in the observation group was higher than that in the control group (P<0.05); both of the visual acuity and the visual field were continuously improved in 1 week and 3 months after operation in two groups (P<0.05), and the observation group was better (P<0.05); The corneal scattered photometric was significant increased in both two groups in 1 week after the operation significantly (P<0.05), while the corneal scattered photometric reduced back to preoperative in 3 months (P<0.05), and there were no difference between the two groups (P>0.05); and the complications of phacoemulsification of the observation group was lower than the control group (P<0.05). No adverse drug reactions were observed in both two groups. Conclusion: There was a good curative effect of Xuesaitong soft capsules combined with phacoemulsification in treating non-proliferative diabetic retinopathy (NPDR) and cataract, and it can improved the sight and average visual defect, and lower the complications of phacoemulsification.