To observe the clinical effects of modified Taohong Siwu Decoction in the treatment of femoral head necrosis of qi stagnation and blood stasis type, and analyze its mechanism. Methods:A total of 102 patients in the outpatient department of orthopedics, and hospitalization department in our hospital from January 2015 to January 2017 were randomly selected and divided into treatment group and control group according to the order of treatment, with 51 cases in each group. The two groups were treated with basic treatment, while the control group was treated with extracorporeal shock wave therapy. The treatment group was treated with modified Taohong Siwu Decoction, and the treatment last for 8 weeks. Before and after treatment, the clinical efficacy, hip Harris score and bone mineral density were evaluated, and the changes of serum osteocalcin and hemorheology were detected and analyzed. Results:After 8 weeks of treatment, the clinical efficacy of the treatment group and the control group were compared. The total efficiency of the treatment group (92.15%) was better than the control group (82.35%) (P<0.05); after treatment, Harris hip score, bone density and serum osteocalcin were significantly improved in treatment group compared with before treatment, which was better than the control group (P<0.05); the hemorheology indexes of two groups were significantly lower than that before treatment, and the treatment group was better than the control group (P<0.05). Conclusion:Taohong Siwu Decoction can effectively alleviate the clinical symptoms of patients with femoral head necrosis of qi stagnation and blood stasis type, and improve the local blood coagulation state, which is conducive to the recovery of osteonecrosis, and it is worthy of clinical application.