To discuss the clinical curative effects of modified Gegen Qinlian Decoction on damp-heat type diabetic nephropathy, and observe the effects on vascular endothelial growth factor and urinary albumin excretion rate of the patients. Methods: A total of 70 patients with damp-heat type diabetic nephropathy who were admitted and treated in People's Hospital of Hubei Medical College from April 2011 to April 2016 were selected into the study. All patients were randomly divided into control group and observation group, 35 cases in each group. The two groups of patients were treated with conventional treatment, and the observation group was treated with modified Gegen Qinlian Decoction based on the conventional treatment. Both of the two groups were continuously treated for 8 weeks. Levels of TCM syndrome integration, urine trace albumin excretion rate (mAlb), 24 hour urine protein quantitation (Upro/24 h), serum creatinine (Scr), glycosylated hemoglobin (HbAlc), urea nitrogen (BUN), 2 hour postprandial blood glucose (FPG), triglycerides (TG) and peripheral blood vascular endothelial growth factor (uVEGF) of two groups were detected before and after treatment. Results: TCM syndrome integration in the two groups both declined after treatment, and it was more significantly in the observation group (P<0.05). The modified Gegen Qinlian Decoction can evidently decrease the levels of mAlb, Upro/24 h, Scr, BUN, HbAlc, FPG, TG, which had statistical significance compared with the two groups (P<0.05). VEGF level of the two groups both declined after treatment, and the decrease of observation group was more sharply (P<0.05). Conclusion: Modified Gegen Qinlian Decoction has ideal curative effect on damp-heat type diabetic nephropathy, which can significantly improve the patients' clinical symptoms and correct the lipid metabolism disorders, and may achieve the goal of treatment for diabetic nephropathy by blocking uVEGF secretion.