To investigate the effect of ginkgolide injection on the treatment of ischemic stroke and the influence on blood lipids and cytokines in patients with ischemic stroke.Methods:A total of 82 patients with ischemic stroke admitted in our hospital from March 2015 to September 2016 were randomly divided into observation group of 41 cases and control group of 41 cases according to the random number table method.The control group was treated with conventional western medicine, while the observation group was treated with ginkgolide injection on the basis of the control group.The two groups were treated for 14 d.The therapeutic effects of the two groups were compared before and after treatment, and CSS score, MMSE score, serum lipids and cytokines, and adverse reactions were observed.Results:The total efficiency of the observation group (90.24%) was higher than the control group (70.73%) (P<0.05); CSS, LDL-C, TG, TC score, TNF-α and MMP-9 and IL-6 were decreased after the treatment in the two groups, while the MMSE score increased (P<0.05); CSS score, LDL-C, TG, TC, TNF-α, MMP-9, IL-6 levels after treatment in the observation group than in the control group, while MMSE score higher than the control group (P<0.05); the two groups had no significant adverse reactions.Conclusion:Ginkgolide injection is effective in the treatment of ischemic stroke, and can improve the blood lipids and cytokines in patients with ischemic stroke.