To investigate the efficacy of acupuncture treatment on stroke patients with depression and effects on neurological function. Methods:A total of 134 stroke patients with depression from First Hospital Affiliated to Tianjin Medical University from June 2015 to December 2016 were selected. They were randomly divided into observation group (n＝67) and control group (n＝67). The control group was treated with Mirtazapine Tablets, while the observation group was treated with acupuncture combined with the control group. The two groups were treated for 8 weeks. The therapeutic effects were compared between the two groups before and after treatment. The NIHSS score, HAMD score, Balthel index score and the changes of plasma Cor and neuropeptide Y were observed before and after treatment. Results:The total efficiency of the observation group (95.52%) was higher than the control group (76.12%) (χ2=10.364, P<0.05); the NIHSS score and HAMD score decreased in two groups after treatment, and there were significant differences (observation group, t＝17.890, 21.575, control group t＝10.243、9.808, P<0.05); NIHSS score and HAMD score in the observation group after treatment were lower than the control group (t＝9.557, 11.939, P<0.05); Balthel score of the two groups after treatment increased, and there were significant differences (observation group t＝24.793, control group t＝12.827, P<0.05); Balthel score of the observation group after treatment was higher than the control group (t＝11.333, P<0.05); plasma Cor levels decreased, and neuropeptide Y creased in two groups after treatment with statistical difference (observation group t＝10.089, 23.183, control group t＝5.388, 17.019, P<0.05); the plasma Cor of observation group after treatment was higher than the control group, while neuropeptide Y was lower than the control group (t＝5.388, 7.364, P<0.05). Conclusion:Acupuncture in the treatment of stroke patients with depression has significant curative effects, and can improve the neurological function of patients, with important research significance.