To investigate the curative effect of acupoint injection technique of capreomycin combined with moxifloxacin in the treatment of multi drug resistant pulmonary tuberculosis, and effects of moxifloxacin on patients' compliance.Methods:From March 2012 to March 2014, 108 patients with multi drug resistant pulmonary tuberculosis were selected and divided into the observation group and the control group by random number table method.The observation group was given 6CmMxPtoPaZ/18MxPtoPaZ, and the control group was given 6CmVPtoPaZ/18VPtoPaZ, which by the improved Cm technique and acupoint injection, were given a full course of treatment of liver Silibin Meglumine Tablets.The efficacy and adverse reactions of the two groups was studied.Results:After 6 months and 24 months after treatment, the patients' self improvement rate, the rate of lesion digestibility and cavity healing rate were significantly higher than those in the control group, and the difference was statistically significant (P<0.05).At 6 months after treatment, the sputum negative rate of observation group was significantly higher than that of the control group (P<0.05), but at 24 months the negative rate of sputum culture of two groups were not significantly different (χ2=1.87, P>0.05).There was no significant difference in adverse reaction between the observation group and the control group.Conclusion:The modified method of acupoint injection capreomycin combined with moxifloxacin in the treatment effect was better in combination with levofloxacin.Although the moxifloxacin group cost is higher, the cure rate is high.It is worthy of clinical application in treating multi drug resistant pulmonary tuberculosis.The self improvement rate and other assessment index of efficacy have good consistence, which can be used as determination of clinical effect.