To study the clinical effects of western medicine combined with traditional Chinese medicine oral administration and external application in the treatment of subacute thyroiditis.Methods:A total of 64 cases of subacute thyroiditis were admitted and treated by Puren Hospital of Wuhan City from May 2015 to May 2017.According to random table method,patients were randomly divided into treatment group and control group,with 32 cases in each group.The Chinese medicine group took western medicine combined with traditional Chinese medicine oral administration and external application,and the control group only took the conventional western medicine treatment.The improvement situations of patients in the two groups were observed including symptoms:thyroid swelling subside time,thyroid pain relief time and antipyretic time,physicochemical index:free triiodothyronine (FT3),free tetraiodothyronine (FT4),thyroid stimulating hormone (TSH),erythrocyte sedimentation rate (ESR).C-reactive protein (CRP),recurrence,safety index and efficacy of TCM syndromes.Results:The time of thyroid swelling subsided,the remission time of thyroid pain and the time of fever abatement in the TCM group were shorter than those in the control group,and the differences were statistically significant (P<0.05); The differences of physicochemical indexes of the two groups of patients before and after treatment were statistically significant (P<0.05); There were significant differences in physical and chemical indexes between the treatment group and the control group after treatment (P<0.05); The total effective rate of TCM syndrome of TCM group (93.75%) was better than that of control group (71.88%),and the difference was statistically significant (P<0.05); The recurrence rate of TCM group (6.66%) was significantly lower than that of the control group (21.74%),and the difference was statistically significant (P<0.05);The incidence rate of hormone related side reaction in TCM group (3.13%) was significantly lower than that in control group (15.63%),and the difference was statistically significant (P<0.05).Conclusion:Western medicine combined with traditional Chinese medicine treatment of subacute thyroiditis can shorten the course and improve the therapeutic effect,reduce the recurrence rate and reduce the hormone related adverse reaction,which was worthy of promotion in the clinic.