Abstract:The pharmaceutical quality by design (QbD) encourages the use of innovative pharmaceutical technologies and equipment to improve drug quality and production efficiency. Continuous manufacturing refers to the process of supplying raw materials and producing the final product without interruption over a period of time. Compared with batch production, continuous manufacturing has the characteristics of less floor space, shorter production cycle, higher intelligence, easier process scale-up and higher product quality consistency, and meets the development trend and demand of drug production in the future. This paper summarizes the key technologies and methods of continuous pharmaceutical processes, including continuous feeding, continuous mixing, continuous wet granulation, and full-scale continuous production process of oral solid dosage preparations, chemical products and biological products. The applications of residence time distribution (RTD) model and process analytical technology (PAT) and other advanced control methods to the continuous pharmaceutical processes were also reviewed to provide references for the development and manufacturing of Chinese medicine preparations.