The quality by design (QbD) based pharmaceutical quality system has gradually incorporated intelligent tools, such as smart equipment, industrial information software, big data and cloud computing, into its production control and knowledge management systems. Intelligent manufacturing has led the change of Chinese medicine industry. In the face of emerging new technologies and intelligent manufacturing tools, this paper introduced the intelligent manufacturing maturity model, evaluated and analyzed the current status of Chinese medicine manufacturing. It was concluded that the Chinese medicine manufacturing was mainly at the stage of digitization, standardization and integration, and would move towards the optimization level and leading level in the future. Four key technologies——continuous manufacturing, information integration, intelligent simulation and intelligent application were proposed for intelligent manufacturing of Chinese medicine. The deep integration of artificial intelligence and advanced manufacturing technologies would spawn a new generation of intelligent manufacturing of Chinese medicine by realizing the application of process knowledge and model, as well as the closed loop of production process perception and control decision.