To explore the effects of Kuntai Capsule+Zhibai Dihuang Pills+Vitamin E Capsule in the treatment of perimenopause syndrome. Methods:A total of 125 cases of patients with perimenopause syndrome who were treated in our hospital from January 2015 to May 2016 were randomly divided into two groups. The 75 patients in the observation group were treated by Kuntai capsule+Zhibai Dihuang pills+vitamin E capsule, and the 50 patients in the control group were treated by hormone replacement therapy (HRT). Clinical efficacy was observed by testing E2 and FSH levels of the serum, endometrial thickness, Liver and kidney function index (ALT、AST、BUN), KI score after treatment for 3 months and 6 months. Results:E2 and FSH levels of the serum in the observation group after treatment for 3 months and 6 months were significantly lower than the control group; Endometrial thickness were not significantly changed between the two groups after treatment for 3 months and 6 months; Liver and kidney function index (the levels of ALT、AST、BUN in the serum) were not significantly changed between the two groups after treatment for 3 months and 6 months; KI score after treatment for 3 months and 6 months was not significantly changed between the two groups; The incidence of adverse reactions in the observation group was significantly lower than the control group after treatment for 3 months and 6 months. Conclusion:Kuntai Capsule+Zhibai Dihuang Pills+Vitamin E Capsule can effectively improve perimenopause syndrome, regulate sex hormone levels, without significant adverse reactions and with high safety.