To explore the clinical efficacy and the influence of Sofren injection on the inflammatory factor and left ventricular function in the treatment of acute myocardial infarction (AMI) patients after undergoing percutaneous coronary intervention (PCI). Methods:A total of 80 cases AMI patients who were treated with PCI in our hospital from May 2014 to May 2016 were elected and randomly divided into control group and observation group, with 40 cases were for each group. Control group were treated with conventional therapy, while observation group were treated combined with Sofren injection. Two weeks as one treatment course, both groups were treated continuously for 2 courses. The clinical efficacy of 2 groups after treatment was calculated, and the changes of serum inflammatory factors were detected and compared; the left ventricular function indexes of 2 groups by color doppler ultrasound instrument were measured and compared, and the major adverse cardiac events (MACE) in 2 groups during following-up were recorded. Results:The total effective rate of observation group (775%) was higher than control group (550%) significantly (P<005); Compared with before treatment, the levels of serum inflammatory factors of MPO, hs-CRP, IL-6, TNF-α and the levels of serum heart function indexes of BNP, cTnT, CK-MB in 2 groups decreased significantly after treatment (P<005 or P<001), and those of observation group were lower than that in control group (P<001); Compared with before treatment, the LVEDD of 2 groups and the LVESD of observation group decreased significantly after treatment (P<005 or P<001), and observation group was less than control group (P<005 or P<001); the LEVF of 2 groups and the FS of observation group increased significantly after treatment (P<001), and observation group was greater than control group (P<005 or P<001). The MACE occurrence rate of observation group was 300%, which decreased significantly compared with the 550% of control group during following-up (P<005). Conclusion:The clinical efficacy of Sofren injection is remarkable in the treatment of AMI patients after undergoing PCI, which can reduce the inflammatory factors levels, relieve the myocardial damage, improve left ventricular function and reduce the occurrence of MACE.