To observe and compare clinical efficacy of Chinese herbal medicine combined with EEG biofeedback in the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and to evaluate its efficacy objectively and explore its mechanism. Methods:A total of 50 cases of ADHD children were collected in July 2015 to March 2017 in Dongzhimen hospital of Beijing university of Chinese medicine. Cases were randomly divided into Chinese herbal medicine group and Chinese herbal medicine+EEG biofeedback groups, with 25 cases in each group. Finally, a total of 37 cases were observed clinically. The outcome was evaluated with Number Cancellation Test, Snap-IV scale score Test, Brain Electrophysiological Test and Conners Index of Hyperactivity Test before and after treatment. Results:After treatment, both groups improved in the Snap-IV scale score Test, the Number Cancellation Test and the frequency variation of the brainwave (P<005). The hyperactivity index did not improve significantly. Conclusion:Both groups are effective for ADHD treatment, and the comprehensive treatment is better in the overall symptoms than Chinese herbal medicine.