To explore the clinical effects of combination of traditional Chinese and western medicine in the treatment of metabolic syndrome (MS) and its effects on blood lipid and blood glucose. Methods:A total of 108 patients with MS enrolled in our hospital from February 2014 to September 2016 were divided into control group (n＝54) and observation group (n＝54). The control group was treated with metformin tablets and hypoglycemic and atorvastatin, while the observation group on the basis of the control group was treated with Jianpi Lishi Huazhuo Decoction. After 1 week for a course of treatment, the 2 groups were continuously treated for 4 courses. The clinical efficacy in the 2 groups before and after treatment was compared; the blood lipids, blood glucose changes of the 2 groups were detected and compared, and the mean body mass index (BMI) changes were detected. Results:The total effective rate in the observation group was higher than that in the control group (8519%) and the difference was statistically significant (P<005). The levels of HDL-C was significantly higher than before treatment, BMI while TC, TG, LDL-C and FPG, 2 hPG, HbAlc in the 2 groups were significantly lower than those before treatment. The levels of BMI, TC, TG, LDL-C and FPG, 2 hPG, HbAlc were significantly lower in the observation group than those in the control group. HDL-C was significantly higher than that in the control group (P<005 or P<001). Conclusion:The combination of traditional Chinese and western medicine in the treatment of MS has significant effects, which can effectively control the blood glucose, blood lipid levels and reduce BMI.