To investigate the clinical efficiency of Dingkun Pellet combined with hormone in the treatment of patients with hypomenorrhea of kidney deficiency and liver depression type and the influence on the endometrium. Methods:A total of 300 patients with hypomenorrhea of kidney deficiency and liver depression type who were treated in our hospital from January 2011 to January 2015 were selected and randomly divided into control group and test group, with 150 cases in each group. Both groups received the regular estrogen and progestin hormone treatment, and the test group added Dingkun Pellet. One treatment course included 2 menorrhea circle time, and the treatment lasted 2 courses. Results:After treatment, the menorrhea blood quality, menorrhea lasting time, endometrium thickness and serum LH, E2 and P levels of the 2 groups all increased significantly (P<00 5or P<001), and the rangeability in the test group was significant larger than the control group (P<001). The total effective rate was 9043%, which was higher than that 6457% of control group (P<001). Conclusion:The clinical efficiency of Dingkun Pellet combined with hormone in the treatment of patients with hypomenorrhea of kidney deficiency and liver depression type is better than sex hormone alone, which can outstandingly increase menorrhea blood quality, menorrhea lasting time, endometrium thickness and sex hormone levels.