To explore the clinical efficacy of Xueshuantong injection in the treatment of coronary atherosclerotic heart disease (CHD) and analyze the effects on the hemorheology and platelet activation function. Methods:A total of 95 cases of CHD patients in cardiology department of our hospital from Sep. 2014 to Jan. 2017 were selected and divided into control group (n＝47) and expriment group (n＝48) according to the random number table. The control group was treated with conventional foundation treatment and symptomatic treatment, and experiment group was treated with Xueshuantong injection on the basis of control group. Both groups were treated for 1 month continuously. The clinical efficacy and electrocardiogram efficacy of 2 groups after treatment was statisticsed; the changes of hemorheology indexes and platelet activation function indexes of 2 groups before and after treatment were detected and compared. Results:Compared with control group, the marked effective rates of clinical efficacy and electrocardiogram efficacy in 2 groups increased significantly, and the inefficiency decreased significantly (P<001). The total effective rates of clinical efficacy and electrocardiogram efficacy in experiment group were 9167% and 8750% respectively, which were higher than 9167% and 8750% in control group (P<001); Compared with before treatment, the whole blood high/low shear viscosity, red blood cell aggregation index of 2 groups and the plasma viscosity, hematokrit of experiment group decreased significantly (P<001), and experiment group was lower than control group (P<001); Compared with that before treatment, the GMP-140 of 2 groups and the MAR of experiment group decreased significantly, and experiment group was lower than control group (P<001). Conclusion:Xueshuantong injection can contribute to improve the hemorheology of CHD patients, adjust the platelet activation function, improve the clinical symptoms effectively, and the efficacy is better significantly than conventional treatment.