To investigate the curative effect and safety of the elemenum emulsion combined with TACE treatment in treating the middle-late stage of liver cancer. Methods:A total of 80 cases of middle-late liver oncology who were treated in Shanghai university of traditional Chinese medicine affiliated hospital of traditional Chinese medicine from February 2015 to February 2015 were selected and randomly divided into observation group (n＝40) and the control group (n＝40). The control group was given conventional treatment, and the observation group was given joint elemenum emulsion treatment on the basis of control group. TCM syndrome curative effect, liver function, quality of life and the incidence of adverse reactions of two groups were observed. Results:The improvement rate of TCM syndrome in observation group (8000%) was significantly greater than the control group (4750%) (P<005); The improvement of ALT, AST, GGT, TBIL in observation group was better than control group (P<005); after treatment, KPS score (8649±1203) of the observation group was significantly greater than the control group (7414±1367) (t=4289, P<005); The adverse reaction conditions were similar between the two groups, without statistical significance (P<005). Conclusion:Elemenum emulsion combined with TACE in the treatment of patients with middle-late stage of liver cancer can significantly improve the clinical symptoms, liver function and quality of life, and adverse reactions can alleviate, which is worthy of clinical promotion.