To explore the effects of Bushen Quyu decoction combined with danazol on the serum estrogen/progesterone and prostaglandin in the treatment of patients with endometriosis. Methods:A retrospective analysis of 122 cases of patients with endometriosis in gynecology clinic of our hospital from February 2016 to January 2017 were selected and divided into treatment group (n＝61) and control group (n＝61) according to therapeutic method. Patients in the control group were treated with danazol, and those in the treatment group were treated with Bushen Quyu decoction on the basis of what was used in the control group. All the patients of the 2 groups were treated continuously for 3 months. The clinical effects of patients in the 2 groups were compared; the serum estrogen/progesterone, humoral/cellular immune indexes and prostaglandin levels of patients in the 2 groups were detected and compared before and after treatment; the adverse reactions of the 2 groups were observed and compared. Results:After treatment, the clinical total effective rate of the treatment group was 8197%, which was significantly higher than 6393% of the control group (P<005); after treatment, the levels of P, E2, LH and FSH in the 2 groups were significantly lower than those before treatment, and the levels in the treatment group were lower than those in the control group (P<005 or P<001); after treatment, the levels of IgA, IgG and IgM in the 2 groups were significantly lower than those before treatment, and the levels of C3 and C4 were significantly higher than those before treatment. The differences between the 2 groups were significant (P<005 or P<001); after treatment, the proportion of CD4+, CD3+ and CD4+/CD8+ in the 2 groups were significantly higher than those before treatment, and the levels in treatment group were higher than those in the control group (P<005). There was no significant difference of the proportion of CD8+ cells compared with before treatment and between the 2 groups (P>005); after treatment, the levels of PG E2, PG F2α and TXB2 in the 2 groups were significantly lower than those before treatment, and 6-k-PG F1 level was significantly higher than that before treatment. The difference between the 2 groups was significant (P<005 or P<001); there was no significant difference in the incidence of adverse reactions between the 2 groups (P>005). Conclusion:Bushen Quyu decoction combined with danazol can regulate the immune function in patients with endometriosis, improve the serum estrogen/progesterone levels, enhance resistance of patients, relieve pain, which had significant effects and was safe and feasible.