To observe the clinical effects of Du-regulating and cerebrovascular-unblocking acupuncture therapy on depression after cerebral infarction. Methods:A total of 68 eligible cases of patients diagnosed with depression after cerebral infarction were admitted into Handan Hospital of Traditional Medicine from October 2015 to October 2016, which were randomly divided into the observation group and the control group according to the random number table. All the patients were treated with conventional western medicine therapy and conventional acupuncture therapy. On the basis of the conventional therapies, patients in the observation group were treated with Du-regulating and cerebrovascular-unblocking acupuncture therapy, whereas patients in the control group were treated with oral administration Escitalopram oxalate Tablets. Hamilton depression scale (HAMD), clinical neurological function deficit scale (CNFD) and Barthel Index (BI) were used to evaluate the patients' depression degree, nervous functional defects degree and living ability before treatment, 4 weeks and 8 weeks after treatment respectively. In addition, adverse reactions were also observed. Results:The total effective rate was 9412% in the observation group, compared with 8182% in the control group, and the difference was statistically significant (P<005); the observation group was superior to the control group in improving the HAMD (P<005), CNFD and BI scores (P<005), and the differences were all statistically significant. Moreover, the grades improved more significantly with treatment time extension. Conclusion:Escitalopram oxalate, together with Du-regulating and cerebrovascular-unblocking acupuncture therapy were effective for depression after cerebral infarction, and Du-regulating and cerebrovascular-unchocking acupuncture therapy was much better in promoting the recovery of neural function and enhancing the quality of life.