To observe the effects of herb-partitioned moxibustion on the expression of ICAM-1 and PPARγ in rats with endometriosis. Methods:A total of 34 female rats were randomly divided into 8 rats as control group and 24 rats for model establishment group. The endometriosis model was established by modified methods. 24 model rats were randomly divided into the model group, the herb-partitioned moxibustion group and the Danazol group with 8 rats in each group. The expression of ICAM-1 and PPARγby was detected by western blotting method. Results:Compared with the control group, the expression of ICAM-1 in the model group, the herb-partitioned moxibustion group and the Danazol group was significantly increased (P<005); compared with the model group, the expression of ICAM-1 in the herb-partitioned moxibustion group and danazol group was significantly decreased (P<005); compared with the control group, the expression of PPARγ in the model group, herb-partitioned moxibustion group and Danazol group was significantly decreased (P<005). Compared with the model group, the expression of PPARγ in the herb-partitioned moxibustion group and the Danazol group was significantly increased (P<005). Conclusion:Herb-partitioned moxibustion can inhibit the expression of ICAM-1 and boost the expression of PPARγ, which can inhibit the adhesion of endometrial cells and prevent angiogenesis.