To verify the clinical efficacy of small needle knife therapy in the treatment of knee osteoarthritis, and to analyze the correlation between different pathological factors and efficacy. Methods:A total of 200 cases of patients with knee osteoarthritis who were admitted and treated in our hospital from January 2011 to September 2011 were selected. All the patients were evaluated for the degree of pathological changes and treated by small needle knife therapy. The curative effect was compared four weeks and eight weeks after treatment. The logistic regression analysis was conducted for different pathological characteristics and treatment results. Results:There were 5 cases of shedding and loss to follow-up. The other 195 patients were followed up after the small needle knife treatment. The total effective rates were 952% and 961% four weeks and eight weeks after treatment, which was statistical significant when compared with before treatment (P<005). Logistic regression analysis showed that the radiographic classification, number of interventricular lesions， course of disease, weight, joint deformity were the independent risk factors that affected clinical efficacy, namely the above factors were becoming worse, and the clinical efficacy became invalid. Conclusion:Small needle knife therapy in the treatment of knee osteoarthritis has certain efficacy, but proper treatment should be selected based on the severity of each patient, so as to develop personalized needle knife therapy for patients.