To study the effects of different decoction methods on the effective chemical composition of Scutellaria baicalensis Georgi in Xiaochaihu Decoction. Methods:The contents of effective chemical composition (Baicalin, Baicalein, Wogonin) in Xiaochaihu decoction boiled by deslagging and non-deslagging and then decocting were determined by high performance liquid chromatography. The comparison solution included the Baicalin, Baicalein and Wogonin. The linear relationship of the comparison solution and the precision test, the stability test and the recovery rate test were carried out before the start of the test. Results:The standard curve equation of Baicalin, Baicalein and Wogonin comparison solution were Y＝4 345 73098X888 811 (r=0999 8), Y＝247 826 868X91105 (r=0999 5) and Y＝771 988 974X244 903 (r=0999 9). The RSD of Baicalin, Baicalein, Wogonin reference solution in the precision test, stability test and the recovery test were all lower than 2% and the average recoveries were all higher than 95%. The contents of Baicalin, Baicalein and Wogonin in test solution A were (0364 2±0027 1)mg/mL, (10192 3±0387 5)mg/mL and (18082 2±0746 5)μg/mL, which were higher than (0282 4±0047 8)mg/mL, (8215 0±0354 1)mg/mL and (12698 2±0642 9)μg/mL in test solution B (P<005). Conclusion:The deslagging and then decocting were more beneficial to the dissolution of Baicalin, Baicalein, Wogonin in Xiaochaihu decoction compared to the non-deslagging and then decocting.