To investigate correlation between four diagnosis methods of traditional Chinese medicine and quality of life of patients with chronic heart failure. Methods:Through the method of multi center cross-sectional study, the basic information and TCM diagnosis information of 325 patients met the inclusion criteria of chronic heart failure were collected from September 2013 to December 2014. A total of 36-item Short-Form Health Survey (SF-36) was used to evaluate the correlation between physiological function, physiological role, body pain, general health, vitality, social function, emotional function and mental health and TCM symptoms, which were listed on top 15 and tongue and pulse that frequency of which was greater than 40%. Results:In the symptoms in the top 15, dyspnea, shortage of qi, laziness to speak, fatigue, shortness of breath, loss of appetite, fatigue, edema of lower limbs, and insomnia were remarkably negatively correlated with one or more dimensions and total scores of SF-36 (P<005); tongue inspection was lowly correlated with one or more dimensions and total scores of SF-36 (P<005); pulse diagnosis was lowly correlated with dimensions and total scores of SF-36, without statistically significant difference (P>005). Conclusion:The quality of life of patients with chronic heart failure was associated with four diagnostic information. And the 8 symptoms of dyspnea, shortage of qi, laziness to speak, fatigue, shortness of breath, loss of appetite, fatigue, edema of lower limbs, and insomnia have significant negative correlation with the quality of life of patients. Improvement of the above symptoms can greatly improve the quality of life of patients.