To evaluate the efficacy of acupuncture and clomiphene citrate (CC) treatment for Polycystic Ovary Syndrome (PCOS)-induced infertility. Methods:China National Knowledge Infrastructure, Wanfang Data, VIP China Science and Technology Journal Database covering the period of 1979-2016 were searched. Two reviewers assessed the methodological quality according to Jadad scale and Cochrane Systematic Review independently. Meta-analysis was performed by using the RevMan 53 software. Results:A total of 9 articles involving 769 patients were included .The total effective rate between acupuncture combined with other methods of traditional Chinese medicine and CC combined with other therapies, acupuncture combined with other methods of traditional Chinese medicine and CC alone was that the former was significantly higher than the latter (P<005). There was no significant difference between acupuncture alone and CC combined with other therapies (P>005). The gravidity rate between acupuncture alone and CC combined with other therapies, acupuncture combined with other methods of traditional Chinese medicine and CC alone was that the former was significantly higher than the latter (P<005). As to the improvement of FSH and T, or the reduction of LH, acupuncture combined with other methods of traditional Chinese medicine was definitely prior to CC alone (P<005). Conclusion:As to the total effective rate and the gravidity rate, the treatment of acupuncture combined with other methods of traditional Chinese medicine for PCOS-induced infertility was significantly prior to CC alone or CC combined with other therapies. Comparing with CC alone, acupuncture has an significant advantage in improving the FSH, T score, and reducing the LH score.