To systematically summarize the clinical application of Trichosanthes Cortex injection and evaluate the clinical effects in the treatment of cute cerebral infarction by using the Meta-analysis. Methods:Such databases as CBM, CNKI and wangfang database, PubMed and Cochrane were electronically searched to collect relevant randomized controlled trials (RCT). According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and assessed the methodological quality of included studies. Then, Meta-analysis was conducted using RevMan 53 software. Results:A total of 6 studies was included with 1734 cases. Meta-analysis revealed that Trichosanthes Cortex injection in the experimental group was better than Shuxuening and edaravone in the control group in clinical symptoms efficacy rate, ECG efficacy rate, and hemodynamics improvement. The clinical symptoms efficacy rate was compared in treating acute cerebral infarction (OR=357, 95% CI (281, 454), P<000001). And ECG efficacy rate was compared (RD=028, 95%CI (023, 033), P<000001). The whole blood viscosity at high shearwas of hemorheology was compared (MD＝-186, 95%CI (-224，-148), P<000001)．So were the efficacy rate of haemorheology on whole blood viscosity at low shear (MD＝-246, 95%CI （-320，-173）, P<000001). The Trichosanthes Cortex injection had few adverse reactions with safety. Conclusion:Trichosanthes Cortex injection is effective in the treatment of cute cerebral infarction with high safety. Due to low quality of included literatures, more RCTs with high quality are still needed for further verification.