To systematically review the efficacy of the integrated medicine treatment for type 2 diabetes insulin resistance. Methods:Database including CNKI, VIP, Wan Fang, Sinomed and the Cochrane Library from 2006 to 2016 were searched to identify the randomized controlled trials (RCTS) on integrated medicine treatment for type 2 diabetes insulin resistance. According to the inclusion and exclusion criteria, data was screened and extracted, and assessing methodological qauality was included for studies. Then meta-analysis was performed using RevMan53 software. Results:A total of 16 papers involving 1253 patients were included (644 in the treatment group and 609 in the control group). All studies clearly pointed out the baseline were balanced and comparable. Meta-analysis results showed that traditional Chinese and western medicine therapy were superior to convention galgucocorticoid treatment in increasing clinical efficacy (RR=173, 95%CI[146, 205]), increasing insulin sensitivity index (MD=026, 95%CI[022, 03]), lowering insulin resistance index (MD＝-102, 95%CI[-116，-087]), BMI (MD＝-078, 95%CI[-126，-03]), lowering TC (MD＝-057, 95%CI[-073，-042]; TG (MD＝-078, 95%CI[-126，-030]), LDL-C:SMD＝-046, 95%CI[-059，-032], reducing FINS (SMD＝-069, 95%CI[-081，-057]), FBG (MD＝-09, 95%CI[-109，-07]), HbA1C (MD＝-077, 95%CI[-128，-026]), with statistical significance. Conclusion:The meta-analysis results suggest that the efficacy of the integrated medicine treatment for type 2 diabetes insulin resistance has advantages. Due to limited quantity and quality of the included studies, the above conclusion still needs to be verified by conducting more high quality studies.