To explore the occurrence regularity and pathogenesis of bipolar disorder by using five circuits and six qi. Methods:The data of 233 patients with bipolar disorder were analyzed, focused on the calculation of five circuits and six qi based on the onset time and the distribution of the onset time in different factors of five circuits and six qi. Results:Patients with bipolar disorder were more likely to develop or fluctuate during the year of Tai earth-Shaoyin chief fire – Yangming dryness metal and Shaohuo Jueyin wind wood – Shaoyang phase fire, with statistical significance. Conclusion:The occurrence regularity of bipolar disorder is related to the five circuits and six qi, and its pathogenesis is related to yang qi depression and failing to rise so that to occur, and the disease is mainly in the kidney.