“Correspondence between man and nature” is the result of observation and recording of natural, cosmic, and human body changes in Chinese medicine. The “correspondence between man and nature” concept reveals the relationship between man and nature and the cosmic environment. This relationship is shared by the structure of the human body and the layout of the natural cosmic environment (spatial structure) and the rhythm of human life activity and the rhythm of the natural cosmic movement (time structure). This establishment of the “universe-man” space-time structure integrates the understanding of the human body and the natural universe in Chinese medicine, and summarizes the basis for the treatment of the relationship between man and nature in the Chinese medicine with the concept of “man and nature”. TCM not only discovered the human life rhythm under the influence of the natural universe through the “universe-man” space-time structure, but also used the “universe-man” space-time structure when interpreting and expressing these life activity phenomena. The “universe-man” space-time structure is the basis for building the “universe-man” relationship and also the content of the “universe-man” relationship. From traditional knowledge of the human body and disease awareness to the diagnosis, treatment, and prevention of diseases, TCM implements the “correspondence between man and nature” space-time structure of “universe-man”.