To explore the effect of Yiqi Huoxue herbs on liver microcirculation and hepatic fibrosis indexes for primary liver cancer (PLC) after radiotherapy. Methods:A total of 62 cases of PLC patients in our hospital from January 2016 to January 2017 were selected and randomly divided into control group and treatment group, with 31 cases in each group. Control group was treated with three dimensional conformal radiotherapy, and treatment group was treated with Yiqi Huoxue herbs on the basis of control group. Recent clinical curative effect of 2 groups was statisticsed, and TCM symptoms integral change of 2 groups before and after treatment was evaluated. The change of nailfold microcirculation and hepatic fibrosis indexes of 2 groups before and after treatment was detected and compared. Results:The total remission rate of 2 groups had no significant difference (P>0.05). The total stability rate of treatment group was 96.77%, which was significantly higher than 77.42% of control group (P<0.05); Compared with before treatment, the TCM symptoms integral of abdominal distention, poor appetite, nausea, vomiting, fatigue, pain and jaundice of treatment group after treatment significantly declined, and which in treatment group were significantly lower than that in control group (P<0.05 or P<0.01); Compared with before treatment, the hepatic fibrosis indexes of HA, PC-Ⅲ, C-Ⅳ and LN of 2 groups increased significantly, and the integral of week state of loops, tube shape of loops, flow pattern and total integral decreased significantly. The above indicators in treatment group were lower than that in control group (P<0.05 or P<0.01). Conclusion:Yiqi Huoxue herbs combined with radiotherapy can obviously improve the liver microcirculation of the patients with PLC, reduce the degree of hepatic fibrosis, increase the stability rate of lesions, and reduce patients' pain.