To explore effects of Shugan Jieyu Capsule combine with western medicine on the sleep and cognition in the treatment of liver-depression and qi-stagnation type insomnia patients. Methods:A total of 120 cases liver-depression and qi-stagnation type insomnia patients in our hospital from March 2015 to April 2017 were selected and divided into control group and study group according to random number table method, with 60 cases in each group. Control group was treated with eszopiclone, and study group was treated with Shugan Jieyu Capsule on the basis of control group. Both groups were treated for 4 weeks continuously. The clinical efficacy, the changes of sleep quality and cognitive function indicators before and after treatment of 2 groups were statisticsed and compared. Results:The total clinical efficacy of study group reached up to 95.00%, which was higher than that 63.33% of control group significantly (P<0.01); Compared with before treatment, the sleep time of 2 groups lengthened significantly, and study group was longer than control group (P<0.01). The scores of waked up at night, dreaminess, daily sickness, lack of energy decreased significantly (P<0.05 or P<0.01), and excepted the daily sickness, the others scores of study group were lower than that of control group (P<0.05 or P<0.01); Compared with before treatment, the N2-PL, P3-PL of study group shortened after treatment significantly, and P3 Amp and MoCA score increased significantly. The difference between 2 groups was significant (P<0.01). Conclusion:Shugan Jieyu Capsule combined with eszopiclone can improve the sleep quality and cognitive function of liver-depression and qi-stagnation type insomnia patients, and the clinical efficacy increase significantly and which is better than that of eszopiclone alone.