To explore the effects of puerarin with insulin aspart on biochemical indexes and the fetus umbilical artery, renal artery blood flow mechanics index of pregnant women with gestational diabetes. Methods:A total of 150 cases of pregnant women with gestational diabetes in our hospital from December 2014 and December 2016 were selected and randomly divided into insulin aspart control group and puerarin with insulin aspart observation group, with 75 cases in each group. Control group was given insulin aspart therapy, and observation group was given insulin aspart with puerarin injection on the basis of insulin therapy. The clinical curative effect, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), three acyl glycerin (TG), high-density lipoprotein (HDL-C), cystatin (Cys C), homocysteine (HCY) levels of two groups were compared. Color Doppler ultrasound method was used to determine fetus umbilical artery and renal arterial blood flow mechanics index changes before and after the treatment. The neonatal complications rat was assessed. Results:After treatment, fasting blood glucose (FBG), 2 h blood sugar, glycosylated hemoglobin (HbA1c), total cholesterol (TC), three urinary inhibition acyl glycerin (TG), Cys C and homocysteine (HCY) content of two groups were significantly reduced, and the above index level of observation group was significantly lower than the control group. The difference was statistically significant (P<0.05). HDL-C of observation group was significantly higher than that of control group, and the difference was statistically significant (P<0.05). Compared with control group, umbilical artery, renal artery systolic blood flow velocity and the largest end-diastolic blood flow velocity ratio (S/D) and resistance index (RI) of the observation group was significantly decreased (P<0.05). Compared with the control group, the neonatal complications rate decreased significantly (P<0.05). Conclusion:The puerarin with insulin aspart can improve blood sugar, blood lipid levels in pregnant women who gestational diabetes and reduce the umbilical artery and renal artery blood flow mechanics index, reduce the neonatal complications such as growth restriction, and science and protect the pregnant women and fetus, which is the ideal combination.