To observe the clinical efficacy of Bushen Huoxue Decoction in promoting healing of one-three lower tibial fracture after intramedullary nailing. Methods:A total of 150 patients with one-three lower tibial fracture in our hospital from October 2013 to October 2016 were randomly divided into control group (75 patients) with intramedullary nail fixation used alone and treatment group (75 patients) with Bushen Huoxue Decoction on the basis of control group. The pain relief, time and rate of fracture healing of both groups were compared. Results:The pain relief and fracture healing time of treatment group were significantly better than the control group (P<0.001). There was no difference in fracture healing rate between two groups (P=0.097). Conclusions: The therapy of Bushen Huoxue Decoction combined with intramedullary nail fixation in the treatment of one-three lower tibial fractures can efficiently reduce postoperative pain, shorten fracture healing time, and accelerate fracture union process.