To discuss the effects of WenTong needling combined with Danhong injection on serum of IL-18 and IFN-γ of patients with vascular dementia. Methods:A total of 132 patients with vascular dementia (VD) were selected from April 2015 to October 2016 in our hospitals, and randomly divided into control group, Wentong group, Danhong group, combination group according to the random number table method, with 33 cases in each group. The control group received placebo, and Wentong group received Wentong needling treatment. Danhong group received Danhong injection treatment, and combination group received Wentong needling combined with Danhong injection treatment. Changes in scores of revised Hasegawa dementia scale (HDS-R), serum levels of IL-18 and IFN-γ of all groups were observed before and after treatment, and statistical analysis was performed. Results:Afte treatment, score of HDS and serum of IL-18 and IFN-γin in control group was basically the same as compared with the conditions before treatment (P>0.05); Scores of HDS in Wentong group, Danhong group, combination group were significantly increased as compared with the conditions before treatment (P<0.05), and the highest was combination group, followed by the Wentong group and Danhong group; Serum of IL-18 and IFN-γin of Wentong group, Danhong group, combination group were significantly reduced as compared with the conditions before treatment (P<0.05), and the highest was Wentong group, followed by the Danhong group, and the lowest was combination group; Correlation analysis showed that score of HDS in the Wentong group was not correlated with serum of IL-18 and IFN-γ (P>0.05); Score of HDS in the Danhong group was negatively correlated with serum of IL-18 and IFN-γ (P>0.05); Score of HDS in the combination group was significantly negatively correlated with serum of IL-18 and IFN-γ (P>0.05). Conclusions: Wentong needling combined with Danhong injection treatment of VD has good effect, and lower levels of serum IL-18. IFN-γ is probably one of the molecular biology mechanism.