To study the effect of Yiqi Tongmai Decoction on left ventricular ejection fraction (LVEF), forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and N terminal pro brain natriuretic peptide (Nt-proBNP) of patients with coronary heart disease. Methods:A retrospective analysis was conducted for 84 cases of patients with coronary heart disease and heart failure from February 2015 to February 2017 in our hospital. According to the time of diagnosis, they were divided into study group and control group, with 42 cases in each group. The control group received conventional western medicine treatment, and the study group was given Yiqi Tongmai Decoction on the basis of that. The clinical curative effect of two groups was compared respectively. LVEF, FVC, FEV1 and 6 min walking distance, plasma levels of Nt-proBNP, IL-6, and the changes of TNF-α level of two groups before and after treatment were compared. Results:The total effective rate of study group was 95.24% (40/42), which was significantly higher than the control group 80.95% (34/42). The difference was statistically significant (P<0.05). LVEF, FVC , FEV1 and 6 min walking distance of the study group of after treatment respectively was (52.9±7.5)% and (2.6±0.5)L, (1.7±0.3)L, (413.1±67.2)m, which were significantly higher than those in control group of (45.3±9.6)% and (2.2±0.3)L, (1.4±0.1)L, (365.4±73.2)m. The differences were statistically significant (P<0.05). After treatment, the plasma levels of NT-proBNP of the study group and the control group were (478.7±211.4) pg/mL, (783.5±281.5) pg/mL respectively, which was significantly lower than before treatment. The study group was significantly lower than the control group. The differences were statistically significant (P<0.05). After treatment, the serum IL-6, TNF-α was (10.4±2.5) ng/L, (4.5±0.9) mg/L, which were significantly lower than the control group (17.2±3.3) ng/L, (7.5±1.2) mg/L. The differences were statistically significant (P<0.05). Conclusion:Yiqi Tongmai Decoction can effectively improve the heart and lung function in patients with coronary heart disease and heart failure, and reduce the inflammatory reaction at the same time.