To observe the clinical effect of Chinese herbal medicine Lidan Fangshi Powder on cholelithiasis patients after minimally invasive cholecystolithotomy by visual choledochoscopy lithotomy forceps. Methods:From June 2014 to June 2017, 90 patients with cholelithiasis were admitted to general surgery at Qinhuangdao First Hospital. The patients were randomly divided into observation group (N＝45) and control group (N＝45) according to the random table method. Ninety patients were treated under minimally invasive cholecystolithotomy preserving the gallbladder, and routine nursing and dietary guidance were given after operation in control group. Choledoxone was added in observation group. The gallbladder wall thickness, abdominal gallbladder volume, residual gallbladder volume after meal and recurrence of cholelithiasis before operation and three months after treatment were observed. Results:The total efficiency of observation group (97.78 %) was higher than that of control group (88.89 %) (P<0.05). There was no significant difference in the thickness, FV, RV and E of gallbladder wall between patients before treatment and control group (P>0.05). The comparison of biliary wall thickness, FV, RV and E between the two groups before and after treatment had an improvement (P<0.05). The observation group was superior to the control group in improving the biliary wall thickness, FV, RV and E (P<0.05). There was no significant difference in recurrence of cholelithiasis between the two groups (P>0.05). Conclusion:The treatment of cholelithiasis after minimally invasive cholecystolithotomy preserving the gallbladder by visual choledochoscopy lithotomy forceps with Chinese herbal medicine can effectively improve the clinical effect, reduce the thickness of gallbladder wall and enhance the contraction function of gallbladder.