To explore the effect of Naoxintong Capsule on the treatment of coronary heart disease with hypertension and its effect on endothelial function and blood lipid. Methods:A total of 98 patients with coronary heart disease complicated with hypertension in our hospital from December 2014 to December 2016 were divided into observation group (n=49) and control group (n=49) according to the random number table method. The control group was treated with Extended Release Nifedipine Tablets, while the observation group was treated with Naoxintong Capsule on the basis of the control group. The two groups were treated for 8 weeks. The therapeutic effects of two groups of coronary heart disease and hypertension were compared. Results:The total efficiency of the observation group of coronary heart disease (93.88%) was higher than the control group (75.51%) (P<0.05); the total effective rate of the observation group of hypertension (91.84%) was higher than that of the control group (71.43%) (P<0.05); ET-1 level of the two group after treatment decreased and NO level increased (observation group t=21.103, 24.482, control group t=8.169, 9.121, P<0.05); after treatment, the level of ET-1 in observation group was lower than that in the control group and the level of NO was higher than that of control group (t=11.783, 11.740, P<0.05); TC, TG and LDL-C levels after treatment in the two groups decreased and HDL-C level increased (observation group t=11.042, 20.228, 16.643, 10.630, control group t=5.338, 8.544, 7.832, 4.824, P<0.05); TC, TG and LDL-C levels after treatment in the observation group were lower than that in the control group and the level of HDL-C was higher than that of control group (t=6.821, 11.449, 9.823, 6.450, P<0.05). Conclusion:The therapeutic effect of Naoxintong Capsule in the treatment of coronary heart disease with hypertension is significant, and it can improve the vascular endothelial function and blood lipid of patients with coronary heart disease.