To evaluate the effect of Duhuo Jisheng Decoction on bone metastasis of breast cancer, and to observe its effect on the peripheral blood of patients with the expression of OPG and RANKL. Methods:A total of 50 cases of bone metastasis of breast cancer in our hospital from January 2012 to January 2015 were included. The patients were randomly divided into control group and observation group, with 25 cases in each group. The control group received gemcitabine combined with zoledronic acid treatment, and the observation group was treated with Duhuo Jisheng decoction, 1 dose/day. The two groups were treated for 3 courses. After the end of treatment, the quality of life score, serum tumor markers concentration, incidence of bone related events and peripheral blood OPG and RANKL concentrations in two groups were compared. Results:1) the SF-36 scores of two groups were improved than before treatment (P<0.05), and the observation group was better than the control group (P<0.05); 2) after the treatment of two patients with CA153, CA125, CEA, FER concentrations were decreased after treatment (P<0.05), and the observation group decreased significantly compared with the control group (P<0.05); 3) during the treatment, SREs occurred in both groups. SREs in observation group was significantly lower than the control group (P<0.05); 4) after the intervention of the expression of OPG, RANKL concentration decreased, the amplitude of the observation group changed significantly compared with the control group (P<0.05). Conclusion:Duhuo Jisheng decoction can significantly reduce the risk of bone related events for bone metastasis of breast cancer, improve the quality of life of patients, and its mechanism may be related to regulating the balance of OPG-RANKL system.