To investigate the effect of Shexiang Baoxin Pill combined with atorvastatin on acute myocardial infarction (AMI) and its effect on vascular endothelial function and cardiac function. Methods:A total of 81 patients admitted to our hospital from October 2013 to September 2016 were included in the study and randomized to receive routine treatment. Forty patients in the control group were treated with atorvastatin and 41 patients in the control group was given Shexiang Baoxin Pill based on the control group, with 14 days for a course of treatment. Brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-diastolic diameter (LVESD), nitric oxide (NO), endothelin (ET), and other vascular endothelial function and high sensitivity C-reactive protein (Hs-CRP) before and after treatment were compared. The clinical efficacy and complications were compared. Results:After treatment, the levels of BNP, Hs-CRP, LVEDD, LVESD and ET were decreased, and LVEF and NO were increased. The improvement was significant in the observation group (P<0.05). The total effective rate of the control group was 70.00% (28/40) (P<0.05). The incidence of complications was lower in the observation group (P<0.05), and the total effective rate was higher (P<0.05). Conclusion:Shexiang Baoxin Pill combined with atorvastatin has a significant effect in the treatment of AMI, which can better protect heart function and endothelial function.