To analyze and summarize the composing principles of the Chinese patent medicines for palpitation collected in Pharmacopoeia of People's Republic of China (2015) through traditional Chinese medicine (TCM) inheritance system. Methods:The Chinese patent medicines used for palpitation in Pharmacopoeia were collected and input into the TCM inheritance system. The relationships between disease and symptom, composing principles and new prescriptions were explored and discovered. Results:The basic characteristic and composing principles from 107 Chinese patent medicines and 195 single herbs were analyzed. Palpitation was mainly seen in coronary heart disease, cardiac arrhythmias and hypertension. The most common syndrome was blood stasis, which was followed by qi and yin deficiency, qi and blood stasis. Therefore, herbs with function of nourishing qi and promoting blood circulation were key drugs and were in the highest frequency of usage. The main association rules were discovered to be Radix Polygalae->Radix Angelicae Sinensis and Radix Polygalae->Fried Semen Ziziphi Spinosae by setting the confidence parameter to 0.8. Moreover, 18 core drug combinations and 9 new prescriptions were explored. Conclusion:By TCM inheritance system, we explored and analyzed the Chinese patent medicines in Pharmacopoeia. Palpitation was mostly found in coronary heart disease and blood stasis syndrome. The managements of treatment were promoting blood circulation, nourishing qi, and nourishing liver and kidney. By applying statistical algorithm to the analysis of drug use in Chinese medicine, new ideas and theoretical basis for the treatment of palpitations could therefore be provided.