To verify the efficacy and safety of the diagnosis and treatment of Lyu Renhe's renal collateral syndrome (RCC) in patients with chronic renal disease.Methods:This study adopted the method of prospective cohort study.A total of 310 with primary chronic glomerulonephritis who visited the Nephrology Clinic and Ward of Dongzhimen Hospital from February 2013 to May 2016 were selected.The exposure factor was formed based on the treatment method,and formed renal collaterals remove lump queue,(group 1)：Prof.Lyu Renhe and his inheritors treated patients with oral admonition of decoction based on syndrome differentiation of the renal collaterals remove lump; conventional syndrome differentiation queue (group 2)：not Prof.Lyu Renhe's inheritors treated patients with oral admonition of decoction based on syndrome differentiation of the renal collaterals remove lump.The doses of Chinese herbal decoction were adjusted every 2-4 weeks with at least three clinical doctor visits.The course of treatment was at least eight weeks.Decoctions were given after 8 weeks according to the conditions with 1 year's follow up.Results:The glomerular filtration rate and increase rate of renal collaterals remove lump queue at 8 weeks and 12 months were higher than conventional syndrome differentiation queue.By using analysis of covariance tips,the differences between 8 weeks and 12 months were extremely significant (P<0.001); The TCM syndrome scores of renal collaterals remove lump queue was decreasing.The creatinine level of renal collaterals remove lump queue at 8th week (P=0.029,P<0.05) and the 12th month (P=0.025,P<0.05) were significantly lower than that of conventional syndrome differentiation.The urea nitrogen of renal collaterals remove lump queue at the 8th week (P=0.04,P<0.01) and the 12th month (P=0.028,P<0.05) was significantly lower than that of conventional syndrome differentiation.The 24 h urine protein of renal collaterals remove lump queue at the 6th month (P=0.005,P<0.01) was significantly lower than the conventional syndrome differentiation.Conclusion:Lyu Renhe's syndrome differential of renal collaterals remove lump method is better than the conventional syndrome differentiation method for primary chronic glomerulonephritis.