To evaluate the economics of Xiaojin capsule compared with Xiaojin pill control in the treatment of thyroid nodule,using cost-effectiveness and cost-utility analysis and to provide references for the clinical treatment of thyroid nodules and the formulation of relevant medical policies.Methods:The prospective cohort study design was used,353 cases (Xiaojin capsule group) and 100 cases (control) from 13 hospitals were selected.From the time and place of agreement,the investigators selected all the two research drugs for treatment to meet the criteria for nasopharyngeal exclusion.They were competitively included on a weekly basis and included the first 300 patients in the Jinjin capsule cohort and the first 100 patients in the Xiaojinwan Cohort.Patients were followed up for 6 months.Three layers were designed in accordance with the key variables that affected the curative effect of Xiaojin capsule.Cost-effectiveness and cost-utility analysis were carried out based of the curative effect of TCM syndrome and the reduction of nodule volume as effect indicators,and quality adjusted life years as utility indicators.Results:A total of 454 cases were included.One case was filled out due to incomplete questionnaires.A total of 353 cases of Xiaojin capsules were completed for follow-up and 100 cases of Xiaojinwan cohort.There were three key variables at the baseline between the two groups.P>0.05),so stratified by these three variables.effect on TCM syndrome:the effectiveness and economical efficiency of Xiaojin capsule in Layer 1 were both superior to control.Xiaojin capsule was more economical compared with control in Layer 2.the effectiveness of Xiaojin capsule in Layer 3 was significantly superior to control,though its economy was a bit poor.So it was worthy to choose Xiaojin capsule in order to achieve a better effectiveness.Effect on nodule size Reduction:Cost-effectiveness analysis results of all layers were in accordance with that of TCM syndrome effect.Furthermore,the effectiveness of Xiaojin capsule was more prominent to control.cost-utility analysis:Xiaojin capsule was more economical compared with control in all layers.Conclusion:Xiaojin capsule presented highly effective and economical advantage in the treatment of thyroid nodule compared with control.