To observe the clinical effects of Rujiling granule combined with Xiaojin capsule on mammary hyperplasia.Methods:A total of 660 cases of patients with mammary gland hyperplasia treated in our hospital breast surgery from June 2016 to May 2017 were divided into 3 groups used random number table method,with 220 cases in each group.They were treated with Rujiling granule,Xiaojin capsule,Rujiling granule combined with Xiaojin capsule respectively.And the treatment courses were 3 months in each group.The changes of breast pain score,breast nodule or mass score in the 3 groups were observed,as well as the total effective rate of clinical treatment,the incidence of adverse reactions and other parameters.Results:After 3 courses of treatment,the score of breast pain and breast nodule mass in group A (Rujiling granule group),group B (Xiaojin capsule group),group C (group of Chinese patent medicine) after treatment were reduced significantly than before treatment (P<0.05).Moreover,the breast pain score in group C was significantly lower than that in group A (P<0.05),and the score of breast nodule mass in group C after treatment was significantly lower than that in group A or B (P<0.05).And the total effective rates of A,B and C in 3 groups were 74.5%,86.4 and 93.6%,respectively,that the total effective rate in group C was significantly higher than that in group A or B (P<0.05).6 cases in group A and 5 in group C had an irregular period of menstruation,while other drug related adverse reactions were not founded.Conclusion:Rujiling granule and Xiaojin capsule are all effective in the treatment of mammary gland hyperplasia.Furthermore,Xiaojin capsule combined with Rujiling granule seems to be more effective.They are all worth to be widely used in clinic.