To explore the efficacy and safety of Badu Shengji powder for dressing replacement after anorectal diseases.Methods:A total of 19 patients with anal fistula and perianal abscess in our hospital from April 2017 to August 2017 were included and divided into group A or group B according to their different conditions.There were 7 cases who delayed wound healing for one month assigned to group A,and 12 cases with infected wounds were assigned to group B.All of the patients were stuffed or covered with the sterilized gauze which infiltrationed with Badu Shengji powder and Vaseline mixed in ratio of 1:9.After routine disinfection and removal of the clinging skin,padding or external application was performed,once a day for 7 days.The effective rate,the wound area,the score of pus secretion,the score of local pain and itch,the liver and kidney function and the side effects were observed before and after treatment in the two groups.Results:Both groups had an ideal curative effect,and the total effective rate was 95.7%.The group A (86.7%) had a tendency to had superior curative effect than group B (100%) (P>0.05); the area of wound surface decreased significantly (P<0.05),The purulent rot score was significantly reduced (P<0.05),and the local pain and pruritus score did not decrease significantly (P>0.05).No adverse reactions were found,and liver and kidney functions were not founded abnormal.Conclusion:It is effective and safe for the dressing replacement of the refractory wounds and infected wounds after the operation of anorectal diseases.It is worth to expand the sample size,prolong the observation time,and conduct the randomized controlled trial further more.