To preliminarily observe the clinical efficacy and possible mechanism of the therapeutic effect of Badu Shengji Powder in the treatment of non-lactating mastitis through eliminating pus and necrotic tissues.Methods:A total of 20 patients with non-lactation mastitis were selected in stage of abscess,sinus and divided into the treatment and the control group with 10 cases in each group.In the treatment group,Badu Shengji Powder was evenly spread and covered the pus area of the wound,along with radix scutellariae oil gauze to cover the surface,whereas,in the control group,the wound areas were only covered with radix scutellariae oil gauze.The wounds were treated every other day 7 times for 1 treatment.The size of the tumor mass,the score of the in the wound and the skin condition around the wound were assessed before and after treatment.IL-6 contents in the wound granulation were measured as well as the clinical safety indices of the hepatorenal functions and the level of urine mercury.Results:The scores of breast mass range,the pus and necrotic tissues and the skin conditions beyond wound in the treatment group were significantly lower than those in the control group since the sixth evaluation (P<0.05),among which,the skin temperatures of the wound area were lower than those of control group since the second evaluation.The contents of IL-6 as well as their expressions by histopathologic immunohistochemistry in the peripheral granulation tissue of the treatment group were significantly lower than those in the control group after treatment (P<0.05).The blood routine,hepatoral function and urine mercury of the patients after 14 days of clinical use in the treatment group were all normal and without significant differences as compared with the results of control group.Conclusion:Badu Shengji Powder significantly ameliorated inflammation and promoted wound healing on the patients with non-lactation mastitis through its good efficacies of eliminating pus and narcotic tissues.No clinical adverse events happened within 2 weeks of clinical application.There should be certain values for popularization and application.