To investigate the effect of Chinese medicine on blood glucose antigen 125 (CA125) in patients with recurrent epithelial ovarian cancer.Methods:A total of 92 patients with recurrent epithelial ovarian cancer and ascites who were admitted to our hospital from January 2016 to December 2017 were selected as study subjects.Patients were randomly divided into observation group and control group using random number table method,with 46 cases in each group.Both groups received conventional intraperitoneal chemotherapy,and the observation group was treated with traditional Chinese medicine.After 4 weeks of treatment,the curative effect was evaluated.Before and after treatment,5 mL of fasting venous blood was collected to detect serum CA125.The incidence of adverse reactions during treatment in both groups was calculated.Results:The total effective rates of observation group and control group were 82.61% and 60.87% respectively,and there was significant difference between the two groups (P<0.05).Before treatment,there was no significant difference in serum CA125 levels between the two groups (P>0.05).After treatment,the serum CA125 level was significantly lower in the observation group than in the control group (P<0.05).There was no significant difference in the incidence of nausea and vomiting,diarrhea,leukopenia,thrombocytopenia and renal dysfunction between the two groups (P>0.05).Conclusion:Conventional intraperitoneal infusion chemotherapy combined with the use of traditional Chinese medicine anti-chemotherapy side effects can significantly reduce serum CA125 levels in patients with epithelial ovarian cancer ascites,improve clinical efficacy,and is safe and reliable.