To explore the effect of simiao pills addition and subtraction on gouty arthritis and its influence on laboratory indexes.Methods:A total of 98 patients with gouty arthritis treated in our hospital were acted as the study objectives,and were divided into the observation group and the control group,according to the random digital table method,each group with 49 cases.The control group was treated with conventional western medicine,and observation group was treated with simiao pills addition and subtraction on the basis of the control group,and 2 groups were treated for 1 month continuously.The clinical efficacy of 2 groups was statisticsed and the traditional Chinese medicine (TCM) syndrome scores and related laboratory indexes of 2 groups were compared before and after treatment.Results:The total effective rate of observation group was 89.80%,which was significantly higher than the 79.59% of control group (P<0.05); compared with that before treatment.TCM syndrome scores of 2 groups such as joint pain,swelling,redness,joint function limitation and systemic symptoms significantly decreased after treatment (P<0.01),and observation group was significantly lower than control group (P<0.05 or P<0.01); compared with before treatment,the serum IL-6,IL-8,CRP,TNF-α and the whole blood BUA,ESR and WBC levels of 2 groups decreased after treatment (P<0.01),and observation group was significantly lower than control group (P<0.05 or P<0.01).Conclusion:Simiao pills addition and subtraction in the treatment of gouty arthritis can reduce the levels of inflammatory factors and related laboratory indexes,significantly alleviate the joint symptoms of the patients,and the clinical effect is better than that of western medicine alone.