To observe the clinical efficacy of Wenban Decoction combined with enhanced external counterpulsation in the treatment of PCI postoperative patients with coronary heart disease and the influence on serum TXA2, PGI2, TNF-α and MCP-1. Methods:A total of 60 PCI postoperative patients with coronary heart disease (turbid phlegm and blood stasis) were randomly divided into treatment group and control group with 30 patients in each group. The control group was treated by conventional western medicine and Wenban decoction, and the treatment group was added enhanced external counterpulsation on the basis of the control group with a course of 35 days. The clinical efficacy and the content of serum TXA2, PGI2, TNF-α, MCP-2 before and after the treatment were compared. Results:After the course of treatment, compared with before treatment, the treatment group and the control group had statistically significant differences (P<0.01; P<0.05) in the clinical efficacy and the content of serum TXA2, PGI2, TNF-α, MCP-1; Comparing between groups, the treatment group had statistically significant differences (P<0.01; P<0.05) in the clinical efficacy and the content of serum TXA2, PGI2, TNF-α, MCP-1 from the control group. Conclusion:Wenban decoction combined with enhanced external counterpulsation could effectively improve the clinical efficacy of PCI postoperative patients with coronary heart disease, and improving vascular endothelial function and reducing the level of inflammatory factors may be one of its mechanisms.