To observe the effect of Zengye Runzao Decoction on sex hormone level in the middle-age and old women of Sjogren syndrome and the changes of the function of exocrine gland. Methods:A total of 40 cases of primary Sjogren syndrome were selected from January 2016 to December 2017 in our hospital. According to the random number table method, patients were randomly divided into observation group and control group, with 20 cases in each group. The control group received oral administration of Hydroxychloroquine Sulfate Tablets 0.2 g, 2times/day; patients may be necessary to use artificial tears, drink plenty of water. The observation group was given Zengye Runzao Decoction on the basis of the control group. According to the main symptoms of Sjogren's syndrome, TCM symptom scores were measured, and sex hormone levels and exocrine gland function were detected. The expression level of Tfh cells was detected by flow cytometry. Results:1) After treatment, the clinical symptom scores of the 2 groups were lower than those before treatment (P<0.05), and the TCM symptom scores in the observation group were lower than those in the control group (P<0.05). 2) After treatment, the 2 groups were higher than those before treatment in E2, T and FSH (P<0.05), while LH decreased (P<0.05). The levels of sex hormones in E2, T and FSH in the observation group were higher than those in the control group (P<0.05), while the contrary in the observation group (P<0.05). 3) The secretion of saliva and tear secretion increased after treatment (P<0.05) after treatment with Zengye Runzao Decoction, and was better than that of the control group (P<0.05). 4) The expression level of Tfh cells was lower than before treatment (P<0.05) after treatment with Zengye Runzao Decoction (P<0.05), and the decrease was better than that of the control group (P<0.05). Conclusion:Zengye Runzao Decoction can effectively improve sex hormone level and exocrine gland function in elderly women with Sjogren's syndrome, which may be related to down-regulating the expression of Tfh cells.