To explore the clinical efficacy of Qingrejiedu decoction on periodontitis of menopausal women and the influence on inflammatory factors in gingival crevicular fluid.Methods:A total of 80 cases periodontitis of menopausal women patients were selected and divided into the observation group and the control group,according to different treatment methods,with 40 cases in each group.The 2 groups were given periodontal basic treatment.The control group was given cefradine and metronidazole and the observation group was added with Qingrejiedu Tang on.The 2 groups were treated for 1 month continuously.The clinical efficacy of 2 groups,the improvement of periodontal clinical indexes,the expression of inflammatory factors and other related indexes in gingival crevicular fluid before and after treatment were compared.Results:The total effective rate was 95.00% in the observation group,which was significantly higher than 77.50% in the control group ( P<0.05 ).Compared with those before treatment,the PD,SBI,CAL,PLI in 2 groups after treatment significantly decreased,and the experiment group was significantly lower than control group ( P<0.05 or P<0.01 ).Compared with those before treatment,the expression levels of IL-1β,TNF-α,RANKL in 2 groups after treatment significantly decreased,OPG significantly increased,and the difference between the 2 groups was significant ( P<0.05 or P<0.01 ).Conclusion:Combined with Qingrejiedu Tang on the basis of conventional western medicine treatment can effectively improve the periodontal inflammation and periodontal clinical indicators of menopausal women and promote alveolar bone repair.The clinical efficiency is better than the treatment of traditional western medicine.