To explore the efficacy of Puling Penyankang Granule combined with antibiotics in the treatment of chronic pelvic inflammatory disease.Methods:A total of 118 patients with chronic pelvic inflammatory disease were divided into control group and treatment group according to different treatments.The general antibiotics were given in the control group,and Puling Penyankang Granule combined with antibiotics was given in the treatment group.The clinical efficacy,changes of inflammatory factors,changes of hemorheological targets and recurrence rate after drug withdrawal were compared between two groups.For sub-group comparisons (treatment group and control group),t-test was utilized for continuous variables,while Fisher's exact test and Chi-square test were utilized for categorical variables.Results:The total effective rate in the treatment group was significant higher than the control group (77.59% vs.93.33%,P<0.05); The level of TNF-α were both decreased in the two groups,while the level of IL-2 were both increased.Changes were more significant in the treatment group with statistical difference (P<0.05).Hemorheological targets were improved significantly in the treatment group (P<0.05).The recurrence after drug withdrawal in 3,6 and 12 months in the treatment group were lower than the control group with statistical difference (P<0.05).Besides,significant side effects were not found in both treatment group and control group.Conclusion:The treatment of Puling Penyankang Granule combined with antibiotics improves clinical efficacy,and plays a better role in the anti-inflammatory and improving the microcirculation.